Predicting Mental Health Development in Children

Webpage of the Emmy-Noether Research Group (PI: Dr. Nico Bast) dedicated to improving children’s mental health

Current projects

An overview on the research projects of MIND-CHILD

LOCUS-MENTAL

brainstem functioning as predictor of mental health in preschoolers

DYNAMIC

Dynamic network approach of mental health

SEGA

Sensory processing and gating in autism spectrum conditions

Recent publications

Full publication list is found on Google Scholar

Polzer et al. (2026). Journal of Child Psychology and Psychiatry

Polzer, L., Bast, N., Boxhoorn, S., Mühlherr, A., Mössinger, H., Schütz, M., Freitag, C.M. and Luckhardt, C. (2026), Attenuated selective attention during visual perspective taking in autism: A combined behavior, ERP, and pupillometry study. J Child Psychol Psychiatr. https://doi.org/10.1111/jcpp.70156

Müller et al. (2026). Translational Psychiatry

Müller, A.K., Luckhardt, C., Freitag, C.M. & Bast, N. (2026). Locus coeruleus modulation of neurophysiological sensory selectivity differs in autism and other mental health conditions. Transl Psychiatry. https://doi.org/10.1038/s41398-026-03948-0

Bast et al. (2025). Molecular Autism

Bast, N., Ahmad, J., Mason, L. et al. Locus coeruleus tonic upregulation increases selectivity to inconspicuous auditory information in autistic compared to non-autistic individuals: a combined pupillometry and electroencephalography study. Molecular Autism 16, 41 (2025). https://doi.org/10.1186/s13229-025-00678-w

Raji et al. (2025). Journal of Child Psychology and Psychiatry

Raji, N., Kitzerow-Cleven, J., Kim, Z., Kleber, S.K., Polzer, L., Lemler, C., Ring, M., Taurines, R., Geißler, J., Fröhlich, U., Noterdaeme, M., Bast, N. and Freitag, C.M. (2025), Capturing change in restricted and repetitive behaviour in preschoolers with ASD: A comparison of direct behavioural observation and parent report. J Child Psychol Psychiatr, 66: 1736-1747. https://doi.org/10.1111/jcpp.70009

Bast et al. (2025). European Child and Adolescent Psychiatry

Bast, N., Polzer, L., Raji, N. et al. Early intervention increases reactive joint attention in autistic preschoolers with arousal regulation as mediator. Eur Child Adolesc Psychiatry (2025). https://doi.org/10.1007/s00787-025-02738-1

Lemler et al. (2025). Autism Research

Lemler, C., Kleber, S.K., Polzer, L., Raji, N., Kitzerow-Cleven, J., Kim, Z., Platte, S., Freitag, C.M. and Bast, N. (2025), Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking. Autism Research. https://doi.org/10.1002/aur.70020

Polzer et al. (2024). Scientific Reports

Polzer, L., Schenk, M., Raji, N., Kleber, S., Lemler, C., . . . Bast, N. (2024). Temporal progression of pupil dilation and gaze behavior to emotion expressions in preschoolers with autism spectrum disorder. Sci. Rep., 14(1), 7843. https://doi.org/https://doi.org/10.1038/s41598-024-58480-2

Bast & Boxhoorn et al. (2023). Biological Psychiatry: CNNI

Bast, N., Boxhoorn, S., Supér, H., Helfer, B., Polzer, L., . . . Freitag, C. M. (2023). Atypical Arousal Regulation in Children With Autism but Not With Attention-Deficit/Hyperactivity Disorder as Indicated by Pupillometric Measures of Locus Coeruleus Activity. Biol Psychiatry Cogn Neurosci Neuroimaging, 8(1), 11. https://doi.org/https://doi.org/10.1016/j.bpsc.2021.04.010

Bast et al. (2023). Molecular Autism

Bast, N., Mason, L., Ecker, C., Baumeister, S., Banaschewski, T., . . . the, E. U. A. L. G. (2023). Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case–control study. Molecular Autism, 14(1), 5. https://doi.org/10.1186/s13229-023-00537-6

Research funding

We thank all funding partners that support our research

German Research Foundation:

Daimler and Benz Foundation:

Johanna Quandt Young Academy:

  • member science funding

Polytechnic Foundation of Frankfurt am Main

  • Main-Campus-Educator (post-doc funding)

“The biology of mind bridges the sciences – concerned with the natural world – and the humanities – concerned with the meaning of human experience.”

Eric Kandel

neuroscientist, psychiatrist